Аннотация к книге "Role of Matrix Metalloproteinases in Tissue Remodeling. relevance to pathogenesis of restenosis, aortic aneurism, joint and disc degeneration research"
Matrix metalloproteinases (MMP) are the key enzymes in the pathogenesis of osteoarthritis and inflammatory arthritis. This study was performed on the rat common carotid artery model. This model has better accessibility and reliable injury assessment techniques in comparison to articular cartilage. This groundbreaking study shows that MMP inhibition resulted in a significant decrease in the cell proliferation and the remodeling of the extracellular matrix up to 2 1/2 months after the MMP...
Matrix metalloproteinases (MMP) are the key enzymes in the pathogenesis of osteoarthritis and inflammatory arthritis. This study was performed on the rat common carotid artery model. This model has better accessibility and reliable injury assessment techniques in comparison to articular cartilage. This groundbreaking study shows that MMP inhibition resulted in a significant decrease in the cell proliferation and the remodeling of the extracellular matrix up to 2 1/2 months after the MMP injection versus untreated control group and that these effects were associated with a marked reduction in MMP-2 activity. We strongly advocate testing of non hydroxamate type matrix metalloproteinase inhibitors in larger animals and in the clinical setting for degenerative joint and disc disease. Dr. Margolin's "out of the box" thinking, original study design and sharp indepth analysis are a new important step in restenosis, aortic aneurism and metastasis research as well in developing a disease modifying agent for degenerative disc and joint disease.
Данное издание не является оригинальным. Книга печатается по технологии принт-он-деманд после получения заказа.
Что такое стресс? В чем его суть? Почему он возникает и как его преодолеть? Эти вопросы задает себе каждый человек в определенный момент своей жизни. Стресс возникает, когда мы лишаемся чего-то очень важного, нужного и привычного нам. О.Г. Торсунов предлагает читателю, не имеющему достаточных знаний о тонкостях человеческой психики, взглянуть на стресс другими глазами: согласно ведической концепции,...
Издательство:
Амрита-Русь
Дата выхода: декабрь 2018
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