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Characterization of the MAP Kinase Inhibition Domain of ST5 p70. Identification of a novel protein domain which regulates activation of ERK-2 MAP Kinase

Код 907408

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Аннотация к книге "Characterization of the MAP Kinase Inhibition Domain of ST5 p70. Identification of a novel protein domain which regulates activation of ERK-2 MAP Kinase"

The ST5 gene encodes three proteins with molecular masses of 126, 82 and 70 kDa. The 126 kDa protein contains domains suggestive of a role in regulating signal transduction pathways and activates ERK2 MAP kinase in response to EGF stimulation. This activity is suppressed by p70. More recently, p70 expression has demonstrated the ability to suppress baseline ERK2 activation. In order to identify the p70 domain which mediates suppression of ERK2 activity, HA- tagged p70 variants were constructed...

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Издательство: Книга по требованию
Дата выхода: июль 2011
ISBN: 978-3-6391-0400-4
Объём: 60 страниц
Масса: 111 г
Размеры(высота, ширина, толщина), см: 23 x 16 x 1

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